Moringa oleifera leaf extract ameliorates cisplatin evoked neurotoxicity in male wistar rats
نویسندگان
چکیده
The study was intended to explore the potential role of Moringa oleifera leaf extract (MOLE) on cisplatin (CIS) induced neuronal damage in experimental male rats. In current work, animals were divided into four groups, six each group. Group-1 (Normal) administered with Distilled water 1ml p.o. Group-2 received 5mg/kg, ip. single dose. Group-3 (CIS + MOLE 200mg/kg) orally administrated 200mg/kg, dissolved for 14 days a 5 mg/kg, dose 10 day and Group-4 400mg/kg) 400mg/kg, day. After dosing, rats sacrificed after anesthetizing ketamine. Brain individual rat excised processed evaluation oxidative injury markers like malonyl dialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase histopathological study. treated groups explored (P<0.001) protection against CIS neurotoxicity by elevating GSH, SOD, suppressing MDA brain as well amelioration changes at different doses. Thus, investigational finding revealed that possess benefits anti-cancer drug regulating stress ameliorating death alteration microanatomy brain.
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ژورنال
عنوان ژورنال: IP international journal of comprehensive and advanced pharmacology
سال: 2023
ISSN: ['2456-9542', '2581-5555']
DOI: https://doi.org/10.18231/j.ijcaap.2023.009